5BRO
Crystal structure of modified HexB (modB)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-hexosaminidase subunit beta | polymer | 514 | 58739.4 | 1 | UniProt (P07686) Pfam (PF14845) Pfam (PF00728) In PDB | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta |
| 2 | B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 5 | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A: 43 - 556 (UniProt: P07686)
| PDB | External Database | Details |
|---|---|---|
| Gly 312 | Arg 312 | engineered mutation |
| Ser 313 | Gln 313 | engineered mutation |
| Glu 314 | Asn 314 | engineered mutation |
| Pro 315 | Lys 315 | engineered mutation |
| Asn 452 | Asp 452 | engineered mutation |
| Arg 453 | Leu 453 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 58739.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 138.1 | |
| All* | Total formula weight | 59726.4 |
