5BPU

Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I

Summary for 5BPU

• Entry DOI: 10.2210/pdb5bpu/pdb
• Related: 4MY2
• Descriptor: Norrin, (GGL)EEEEEE, (GGL)EEE, ... (4 entities in total)
• Functional Keywords: wnt signalling pathway, norrie disease protein, cystine-knot like growth factor, ligand for frizzled 4 receptor, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 83144.52

Authors

Chang, T.-H.,Hsieh, F.-L.,Harlos, K.,Jones, E.Y. (deposition date: 2015-05-28, release date: 2015-07-01, Last modification date: 2019-07-10)

• Primary citation: Chang, T.H.,Hsieh, F.L.,Zebisch, M.,Harlos, K.,Elegheert, J.,Jones, E.Y.; Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.; Elife, 4:e06554-, 2015; PubMed: 26158506; DOI: 10.7554/eLife.06554

Experimental method

X-RAY DIFFRACTION (2.4 Å)