5BK8
Cancer-associated SHP2/T507K mutant
Summary for 5BK8
Entry DOI | 10.2210/pdb5bk8/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total) |
Functional Keywords | phosphatase, shp2, ptpn11, t507k, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 61789.72 |
Authors | Yu, Z.H.,Zhang, R.Y.,Zhang, Z.Y. (deposition date: 2019-06-01, release date: 2020-04-08, Last modification date: 2023-09-27) |
Primary citation | Zhang, R.Y.,Yu, Z.H.,Chen, L.,Walls, C.D.,Zhang, S.,Wu, L.,Zhang, Z.Y. Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2. J.Biol.Chem., 295:6187-6201, 2020 Cited by PubMed: 32188694DOI: 10.1074/jbc.RA119.010274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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