5BK8

Cancer-associated SHP2/T507K mutant

Summary for 5BK8

Entry DOI	10.2210/pdb5bk8/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total)
Functional Keywords	phosphatase, shp2, ptpn11, t507k, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	61789.72
Authors	Yu, Z.H.,Zhang, R.Y.,Zhang, Z.Y. (deposition date: 2019-06-01, release date: 2020-04-08, Last modification date: 2023-09-27)
Primary citation	Zhang, R.Y.,Yu, Z.H.,Chen, L.,Walls, C.D.,Zhang, S.,Wu, L.,Zhang, Z.Y. Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2. J.Biol.Chem., 295:6187-6201, 2020 Cited by PubMed: 32188694 DOI: 10.1074/jbc.RA119.010274 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation