5B5K

Crystal structure of Izumo1, the mammalian sperm ligand for egg Juno

Summary for 5B5K

• Entry DOI: 10.2210/pdb5b5k/pdb
• Related: 5EJN
• Descriptor: Izumo sperm-egg fusion protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: cell adhesion, fertilization, egg receptor, gamete adhesion, sperm-egg membrane fusion
• Biological source: Mus musculus (Mouse)
• Cellular location: Membrane ; Single-pass type I membrane protein : Q9D9J7
• Total number of polymer chains: 1
• Total formula weight: 27791.83

Authors

Nishimura, K.,Han, L.,De Sanctis, D.,Jovine, L. (deposition date: 2016-05-11, release date: 2016-07-06, Last modification date: 2023-11-08)

• Primary citation: Nishimura, K.,Han, L.,Bianchi, E.,Wright, G.J.,de Sanctis, D.,Jovine, L.; The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins.; Curr.Biol., 26:R661-R662, 2016; PubMed: 27374339; DOI: 10.1016/j.cub.2016.06.028

Experimental method

X-RAY DIFFRACTION (2.5 Å)