5AYY

CRYSTAL STRUCTURE OF HUMAN QUINOLINATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH THE REACTANT QUINOLINATE

Replaces:  4R3X

Summary for 5AYY

• Entry DOI: 10.2210/pdb5ayy/pdb
• Related: 4R3Y
• Descriptor: Nicotinate-nucleotide pyrophosphorylase [carboxylating], QUINOLINIC ACID (3 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 9
• Total formula weight: 288753.88

Authors

Youn, H.S.,Kim, T.G.,Kim, M.K.,Kang, G.B.,Kang, J.Y.,Seo, Y.J.,Lee, J.G.,An, J.Y.,Park, K.R.,Lee, Y.,Im, Y.J.,Lee, J.H.,Fukuoka, S.I.,Eom, S.H. (deposition date: 2015-09-14, release date: 2016-02-03, Last modification date: 2023-11-08)

• Primary citation: Youn, H.S.,Kim, T.G.,Kim, M.K.,Kang, G.B.,Kang, J.Y.,Lee, J.G.,An, J.Y.,Park, K.R.,Lee, Y.,Im, Y.J.,Lee, J.H.,Eom, S.H.; Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis; Sci Rep, 6:19681-19681, 2016; PubMed: 26805589; DOI: 10.1038/srep19681

Experimental method

X-RAY DIFFRACTION (3.09 Å)