5AYY

CRYSTAL STRUCTURE OF HUMAN QUINOLINATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH THE REACTANT QUINOLINATE

Replaces:  4R3X

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009435	biological_process	NAD+ biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD+ metabolic process
A	0034213	biological_process	quinolinate catabolic process
A	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	1902494	cellular_component	catalytic complex
B	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009435	biological_process	NAD+ biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD+ metabolic process
B	0034213	biological_process	quinolinate catabolic process
B	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	1902494	cellular_component	catalytic complex
C	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009435	biological_process	NAD+ biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0019674	biological_process	NAD+ metabolic process
C	0034213	biological_process	quinolinate catabolic process
C	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
C	1902494	cellular_component	catalytic complex
D	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009435	biological_process	NAD+ biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0019674	biological_process	NAD+ metabolic process
D	0034213	biological_process	quinolinate catabolic process
D	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
D	1902494	cellular_component	catalytic complex
E	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009435	biological_process	NAD+ biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0019674	biological_process	NAD+ metabolic process
E	0034213	biological_process	quinolinate catabolic process
E	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
E	1902494	cellular_component	catalytic complex
F	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009435	biological_process	NAD+ biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0019674	biological_process	NAD+ metabolic process
F	0034213	biological_process	quinolinate catabolic process
F	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome
F	1902494	cellular_component	catalytic complex
G	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009435	biological_process	NAD+ biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016757	molecular_function	glycosyltransferase activity
G	0016763	molecular_function	pentosyltransferase activity
G	0019363	biological_process	pyridine nucleotide biosynthetic process
G	0019674	biological_process	NAD+ metabolic process
G	0034213	biological_process	quinolinate catabolic process
G	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
G	0042802	molecular_function	identical protein binding
G	0070062	cellular_component	extracellular exosome
G	1902494	cellular_component	catalytic complex
H	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009435	biological_process	NAD+ biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016757	molecular_function	glycosyltransferase activity
H	0016763	molecular_function	pentosyltransferase activity
H	0019363	biological_process	pyridine nucleotide biosynthetic process
H	0019674	biological_process	NAD+ metabolic process
H	0034213	biological_process	quinolinate catabolic process
H	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
H	0042802	molecular_function	identical protein binding
H	0070062	cellular_component	extracellular exosome
H	1902494	cellular_component	catalytic complex
I	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0009435	biological_process	NAD+ biosynthetic process
I	0016740	molecular_function	transferase activity
I	0016757	molecular_function	glycosyltransferase activity
I	0016763	molecular_function	pentosyltransferase activity
I	0019363	biological_process	pyridine nucleotide biosynthetic process
I	0019674	biological_process	NAD+ metabolic process
I	0034213	biological_process	quinolinate catabolic process
I	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
I	0042802	molecular_function	identical protein binding
I	0070062	cellular_component	extracellular exosome
I	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue NTM A 401

Chain	Residue
A	ARG138
A	HIS160
A	ARG161
A	MET169
A	LYS171
A	GLU246
G	ARG102

---

site_id	AC2
Number of Residues	9
Details	binding site for residue NTM B 401

Chain	Residue
B	ARG138
B	HIS160
B	ARG161
B	MET169
B	LYS171
B	GLU246
B	HOH501
B	ARG102
B	THR137

---

site_id	AC3
Number of Residues	12
Details	binding site for residue NTM C 401

Chain	Residue
C	THR137
C	ARG138
C	HIS160
C	ARG161
C	MET169
C	LYS171
C	GLU246
C	SER248
C	SER268
C	HOH501
C	HOH503
D	ARG102

---

site_id	AC4
Number of Residues	10
Details	binding site for residue NTM D 401

Chain	Residue
C	ARG102
D	THR137
D	ARG138
D	HIS160
D	ARG161
D	LYS171
D	GLU246
D	SER248
D	SER268
D	HOH501

---

site_id	AC5
Number of Residues	9
Details	binding site for residue NTM E 401

Chain	Residue
E	THR137
E	ARG138
E	HIS160
E	ARG161
E	MET169
E	LYS171
E	SER268
E	HOH501
F	ARG102

---

site_id	AC6
Number of Residues	7
Details	binding site for residue NTM F 401

Chain	Residue
E	ARG102
F	ARG138
F	HIS160
F	ARG161
F	LYS171
F	GLU246
F	SER268

---

site_id	AC7
Number of Residues	9
Details	binding site for residue NTM G 401

Chain	Residue
A	ARG102
G	THR137
G	ARG138
G	HIS160
G	ARG161
G	MET169
G	LYS171
G	GLU246
G	SER268

---

site_id	AC8
Number of Residues	9
Details	binding site for residue NTM H 401

Chain	Residue
H	THR137
H	ARG138
H	HIS160
H	ARG161
H	MET169
H	LYS171
H	GLU246
H	HOH502
I	ARG102

---

site_id	AC9
Number of Residues	9
Details	binding site for residue NTM I 401

Chain	Residue
H	ARG102
I	THR137
I	ARG138
I	HIS160
I	ARG161
I	LYS171
I	GLU246
I	SER268
I	HOH502

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Region: {"description":"Important for hexamer formation","evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17868694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---