5AWM

The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins.

「4M3A」から置き換えられました

5AWM の概要

• エントリーDOI: 10.2210/pdb5awm/pdb
• 分子名称: Stress-activated protein kinase JNK, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: c-jun n-terminal kinase, map kinase, drosophila jnk pathway, transferase
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46064.35

構造登録者

Boonserm, P. (登録日: 2015-07-06, 公開日: 2015-08-05, 最終更新日: 2025-03-19)

主引用文献

Chimnaronk, S.,Sitthiroongruang, J.,Srisucharitpanit, K.,Srisaisup, M.,Ketterman, A.J.,Boonserm, P.
The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins.
Bmc Struct.Biol., 15:17-17, 2015

PubMed Abstract: The c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, engage in diverse cellular responses to signals produced under normal development and stress conditions. In Drosophila, only one JNK member is present, whereas ten isoforms from three JNK genes (JNK1, 2, and 3) are present in mammalian cells. To date, several mammalian JNK structures have been determined, however, there has been no report of any insect JNK structure.

PubMed: 26377800
DOI: 10.1186/s12900-015-0045-1

実験手法

X-RAY DIFFRACTION (1.79 Å)