5AWD
Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ)
5AWD の概要
エントリーDOI | 10.2210/pdb5awd/pdb |
関連するPDBエントリー | 5AWA 5AWB 5AWC |
分子名称 | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
機能のキーワード | immune system, tlr8, adjuvant, vaccine adjuvants, linnate immunity, glycosylation |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 96665.06 |
構造登録者 | |
主引用文献 | Beesu, M.,Caruso, G.,Salyer, A.C.,Khetani, K.K.,Sil, D.,Weerasinghe, M.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58:7833-7849, 2015 Cited by PubMed: 26351878DOI: 10.1021/acs.jmedchem.5b01087 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.05 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード