Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5AVL

Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 32b

Summary for 5AVL
Entry DOI10.2210/pdb5avl/pdb
Related5avi
DescriptorOxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, 2-[4-[4-[[2-[(2-methylpropan-2-yl)oxycarbonyl]-3-oxidanyl-4-(trifluoromethyl)phenyl]methoxy]phenyl]phenyl]ethanoic acid, ... (4 entities in total)
Functional Keywordsagonist, complex, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : Q13133 Q15788
Total number of polymer chains2
Total formula weight36175.03
Authors
Matsui, Y.,Hanzawa, H.,Tamaki, K. (deposition date: 2015-06-17, release date: 2015-08-26, Last modification date: 2023-11-08)
Primary citationMatsui, Y.,Yamaguchi, T.,Yamazaki, T.,Yoshida, M.,Arai, M.,Terasaka, N.,Honzumi, S.,Wakabayashi, K.,Hayashi, S.,Nakai, D.,Hanzawa, H.,Tamaki, K.
Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists
Bioorg.Med.Chem.Lett., 25:3914-3920, 2015
Cited by
PubMed: 26238323
DOI: 10.1016/J.BMCL.2015.07.047
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

건을2024-03-27부터공개중

PDB statisticsPDBj update infoContact PDBjnumon