5AVL
Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 32b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Oxysterols receptor LXR-alpha | polymer | 283 | 32866.4 | 1 | UniProt (Q13133) Pfam (PF00104) In PDB | Homo sapiens (Human) | Liver X receptor alpha,Nuclear receptor subfamily 1 group H member 3 |
| 2 | B | Nuclear receptor coactivator 1 | polymer | 25 | 2806.2 | 1 | UniProt (Q15788) Pfam (PF08832) In PDB | Homo sapiens | NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
| 3 | A | 2-[4-[4-[[2-[(2-methylpropan-2-yl)oxycarbonyl]-3-oxidanyl-4-(trifluoromethyl)phenyl]methoxy]phenyl]phenyl]ethanoic acid | non-polymer | 502.5 | 1 | Chemie (4KQ) | |||
| 4 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A: 182 - 447 (UniProt: Q13133)
| PDB | External Database | Details |
|---|---|---|
| Met 165 | - | initiating methionine |
| Lys 166 | - | expression tag |
| His 167 | - | expression tag |
| Gln 168 | - | expression tag |
| His 169 | - | expression tag |
| Gln 170 | - | expression tag |
| His 171 | - | expression tag |
| Gln 172 | - | expression tag |
| His 173 | - | expression tag |
| Gln 174 | - | expression tag |
| His 175 | - | expression tag |
| Gln 176 | - | expression tag |
| His 177 | - | expression tag |
| Gln 178 | - | expression tag |
| Gln 179 | - | expression tag |
| Pro 180 | - | expression tag |
| Leu 181 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35672.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 502.5 | |
| All* | Total formula weight | 36175.0 |
