5AP7

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Summary for 5AP7

Entry DOI	10.2210/pdb5ap7/pdb
Related	5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6
Descriptor	MONOPOLAR SPINDLE KINASE 1, N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	transferase, mps1, mitosis
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	37263.52
Authors	Gurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.M.,McAndrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,van Montfort, R.,Linardopoulos, S. (deposition date: 2015-09-14, release date: 2015-09-23, Last modification date: 2024-01-10)
Primary citation	Gurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.J.,Mcandrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,Van Montfort, R.L.M.,Linardopoulos, S. Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75:3340-, 2015 Cited by PubMed: 26202014 DOI: 10.1158/0008-5472.CAN-14-3272 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation