5AP1
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Summary for 5AP1
Entry DOI | 10.2210/pdb5ap1/pdb |
Related | 5AP0 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 |
Descriptor | DUAL SPECIFICITY PROTEIN KINASE TTK, 6-{[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile, GLYCEROL, ... (5 entities in total) |
Functional Keywords | transferase, mps1, protein kinase, mitosis, drug resistance |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37303.97 |
Authors | Gurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.J.,McAndrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,van Montfort, R.L.M.,Linardopoulos, S. (deposition date: 2015-09-14, release date: 2015-09-23, Last modification date: 2024-01-10) |
Primary citation | Gurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.J.,Mcandrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,Van Montfort, R.L.M.,Linardopoulos, S. Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75:3340-, 2015 Cited by PubMed: 26202014DOI: 10.1158/0008-5472.CAN-14-3272 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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