5ANT
Potent and selective inhibitors of MTH1 probe its role in cancer cell survival
Summary for 5ANT
Entry DOI | 10.2210/pdb5ant/pdb |
Related | 5ANM 5ANS |
Descriptor | 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 2-(2-methoxyethoxy)-6-(methylamino)-9-(phenylmethyl)-7H-purin-8-one (3 entities in total) |
Functional Keywords | mth1, oncology, hydrolase, nucleotide hydrolysis, inhibition |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639 |
Total number of polymer chains | 3 |
Total formula weight | 61022.98 |
Authors | Kettle, J.G.,Alwan, H.,Bista, M.,Breed, J.,Kack, H.,Eckersley, K.,Foote, K.M.,Fillery, S.,Goodwin, L.,Jones, D.,Lau, A.,Nissink, J.W.M.,Read, J.,Scott, J.,Taylor, B.,Walker, G.,Wissler, L. (deposition date: 2015-09-08, release date: 2016-03-02, Last modification date: 2024-05-08) |
Primary citation | Kettle, J.G.,Alwan, H.,Bista, M.,Breed, J.,Davies, N.L.,Eckersley, K.,Fillery, S.,Foote, K.M.,Goodwin, L.,Jones, D.R.,Kack, H.,Lau, A.,Nissink, J.W.,Read, J.,Scott, J.S.,Taylor, B.,Walker, G.,Wissler, L.,Wylot, M. Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival. J.Med.Chem., 59:2346-, 2016 Cited by PubMed: 26878898DOI: 10.1021/ACS.JMEDCHEM.5B01760 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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