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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5ANT

Potent and selective inhibitors of MTH1 probe its role in cancer cell survival

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0006281biological_processDNA repair
A0006979biological_processresponse to oxidative stress
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008828molecular_functiondATP diphosphatase activity
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0006281biological_processDNA repair
B0006979biological_processresponse to oxidative stress
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008828molecular_functiondATP diphosphatase activity
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006152biological_processpurine nucleoside catabolic process
C0006281biological_processDNA repair
C0006979biological_processresponse to oxidative stress
C0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
C0008828molecular_functiondATP diphosphatase activity
C0016787molecular_functionhydrolase activity
C0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
C0030515molecular_functionsnoRNA binding
C0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
C0042262biological_processDNA protection
C0046872molecular_functionmetal ion binding
C0047693molecular_functionATP diphosphatase activity
C0106377molecular_function2-hydroxy-ATP hydrolase activity
C0106378molecular_function2-hydroxy-dATP hydrolase activity
C0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
C0106433molecular_functionO6-methyl-dGTP hydrolase activity
C0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE RJE A 1157
ChainResidue
ALEU9
ATRP117
AASP119
AASP120
APHE27
AASN33
AGLY34
AGLY36
AGLY37
APHE72
AMET81
AVAL83
site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE RJE B 1157
ChainResidue
BTHR8
BLEU9
BASN33
BGLY34
BGLY36
BGLY37
BPHE72
BMET81
BVAL83
BTRP117
BASP119
BASP120
site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE RJE C 1157
ChainResidue
CTHR8
CLEU9
CASN33
CGLY34
CGLY36
CGLY37
CPHE72
CMET81
CVAL83
CTRP117
CASP119
CASP120
Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG
ChainResidueDetails
AGLY37-GLY58
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues258
DetailsDomain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues63
DetailsMotif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30304478","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OTM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26999531","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FSK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26999531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28035004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GHM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues15
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q7ZWC3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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