5ANM
Crystal structure of IgE Fc in complex with a neutralizing antibody
Summary for 5ANM
Entry DOI | 10.2210/pdb5anm/pdb |
Related | 5ANS 5ANT |
Descriptor | IMMUNOGLOBULIN G, IG EPSILON CHAIN C REGION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | immune system, therapeutic antibody, igg, ige, asthma |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 9 |
Total formula weight | 228131.06 |
Authors | Cohen, E.S.,Dobson, C.L.,Kack, H.,Wang, B.,Sims, D.A.,Lloyd, C.O.,England, E.,Rees, D.G.,Guo, H.,Karagiannis, S.N.,O'Brien, S.,Persdotter, S.,Ekdahl, H.,Butler, R.,Keyes, F.,Oakley, S.,Carlsson, M.,Briend, E.,Wilkinson, T.,Anderson, I.K.,Monk, P.D.,vonWachenfeldt, K.,Eriksson, P.O.,Gould, H.J.,Vaughan, T.J.,May, R.D. (deposition date: 2015-09-07, release date: 2015-09-30, Last modification date: 2024-01-10) |
Primary citation | Cohen, E.S.,Dobson, C.L.,Kack, H.,Wang, B.,Sims, D.A.,Lloyd, C.O.,England, E.,Rees, D.G.,Guo, H.,Karagiannis, S.N.,O'Brien, S.,Persdotter, S.,Ekdahl, H.,Butler, R.,Keyes, F.,Oakley, S.,Carlsson, M.,Briend, E.,Wilkinson, T.,Anderson, I.K.,Monk, P.D.,Von Wachenfeldt, K.,Eriksson, P.F.,Gould, H.J.,Vaughan, T.J.,May, R.D. A Novel Ige-Neutralizing Antibody for the Treatment of Severe Uncontrolled Asthma. Mabs, 6:756-, 2015 Cited by PubMed: 24583620DOI: 10.4161/MABS.28394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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