5ANM

Crystal structure of IgE Fc in complex with a neutralizing antibody

5ANM の概要

• エントリーDOI: 10.2210/pdb5anm/pdb
• 関連するPDBエントリー: 5ANS 5ANT
• 分子名称: IMMUNOGLOBULIN G, IG EPSILON CHAIN C REGION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: immune system, therapeutic antibody, igg, ige, asthma
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 228131.06

構造登録者

Cohen, E.S.,Dobson, C.L.,Kack, H.,Wang, B.,Sims, D.A.,Lloyd, C.O.,England, E.,Rees, D.G.,Guo, H.,Karagiannis, S.N.,O'Brien, S.,Persdotter, S.,Ekdahl, H.,Butler, R.,Keyes, F.,Oakley, S.,Carlsson, M.,Briend, E.,Wilkinson, T.,Anderson, I.K.,Monk, P.D.,vonWachenfeldt, K.,Eriksson, P.O.,Gould, H.J.,Vaughan, T.J.,May, R.D. (登録日: 2015-09-07, 公開日: 2015-09-30, 最終更新日: 2024-01-10)

• 主引用文献: Cohen, E.S.,Dobson, C.L.,Kack, H.,Wang, B.,Sims, D.A.,Lloyd, C.O.,England, E.,Rees, D.G.,Guo, H.,Karagiannis, S.N.,O'Brien, S.,Persdotter, S.,Ekdahl, H.,Butler, R.,Keyes, F.,Oakley, S.,Carlsson, M.,Briend, E.,Wilkinson, T.,Anderson, I.K.,Monk, P.D.,Von Wachenfeldt, K.,Eriksson, P.F.,Gould, H.J.,Vaughan, T.J.,May, R.D.; A Novel Ige-Neutralizing Antibody for the Treatment of Severe Uncontrolled Asthma.; Mabs, 6:756-, 2015; PubMed: 24583620; DOI: 10.4161/MABS.28394

実験手法

X-RAY DIFFRACTION (2.85 Å)