5AJJ

Crystal structure of variola virus virulence factor F1L in complex with human Bid BH3 domain

Summary for 5AJJ

• Entry DOI: 10.2210/pdb5ajj/pdb
• Related: 5AJK
• Descriptor: HOMOLOG OF VACCINIA VIRUS CDS F1L PUTATIVE, BH3-INTERACTING DOMAIN DEATH AGONIST, GLYCEROL, ... (5 entities in total)
• Functional Keywords: viral protein, bcl-2, apoptosis, poxvirus, bid
• Biological source: VARIOLA VIRUS (SMALLPOX); More
• Cellular location: Cytoplasm . BH3-interacting domain death agonist p15: Mitochondrion membrane . BH3-interacting domain death agonist p13: Mitochondrion membrane . Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane: P55957
• Total number of polymer chains: 2
• Total formula weight: 23505.65

Authors

Kvansakul, M.,Colman, P.M. (deposition date: 2015-02-25, release date: 2015-03-25, Last modification date: 2024-01-10)

• Primary citation: Marshall, B.,Puthalakath, H.,Caria, S.,Chugh, S.,Doerflinger, M.,Colman, P.M.,Kvansakul, M.; Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim.; Cell Death Dis., 6:E1680-, 2015; PubMed: 25766319; DOI: 10.1038/CDDIS.2015.52

Experimental method

X-RAY DIFFRACTION (1.75 Å)