5AG4

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A THIAZOLIDINONE LIGAND

Summary for 5AG4

Entry DOI	10.2210/pdb5ag4/pdb
Related	5AG5 5AG6 5AG7 5AGE
Descriptor	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, (2S)-3-(3-chlorophenyl)-2-(pyridin-2-yl)-1,3-thiazolidin-4-one, ... (4 entities in total)
Functional Keywords	nmt, acyltransferase, transferase, drug discovery
Biological source	LEISHMANIA MAJOR
Total number of polymer chains	1
Total formula weight	51781.91
Authors	Robinson, D.A.,Spinks, D.,Smith, V.C.,Thompson, S.,Smith, A.,Torrie, L.S.,McElroy, S.P.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. (deposition date: 2015-01-29, release date: 2015-10-07, Last modification date: 2024-01-10)
Primary citation	Spinks, D.,Smith, V.,Thompson, S.,Robinson, D.A.,Luksch, T.,Smith, A.,Torrie, L.S.,Mcelroy, S.,Stojanovski, L.,Norval, S.,Collie, I.T.,Hallyburton, I.,Rao, B.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode. Chemmedchem, 10:1821-, 2015 Cited by PubMed: 26395087 DOI: 10.1002/CMDC.201500301 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation