5AFK

alpha7-AChBP in complex with lobeline and fragment 2

Summary for 5AFK

• Entry DOI: 10.2210/pdb5afk/pdb
• Related: 5AFH 5AFJ 5AFL 5AFM 5AFN
• Descriptor: ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: transport protein, pentameric ligand-gated ion channels, cys-loop receptor, nicotinic acetylcholine receptor, allosteric modulation, drug discovery
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 5
• Total formula weight: 124440.57

Authors

Spurny, R.,Debaveye, S.,Farinha, A.,Veys, K.,Gossas, T.,Atack, J.,Bertrand, D.,Kemp, J.,Vos, A.,Danielson, U.H.,Tresadern, G.,Ulens, C. (deposition date: 2015-01-22, release date: 2015-05-06, Last modification date: 2020-07-29)

• Primary citation: Spurny, R.,Debaveye, S.,Farinha, A.,Veys, K.,Vos, A.M.,Gossas, T.,Atack, J.,Bertrand, S.,Bertrand, D.,Danielson, U.H.,Tresadern, G.,Ulens, C.; Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor.; Proc.Natl.Acad.Sci.USA, 112:E2543-, 2015; PubMed: 25918415; DOI: 10.1073/PNAS.1418289112

Experimental method

X-RAY DIFFRACTION (2.381 Å)