5AE8

Crystal structure of mouse PI3 kinase delta in complex with GSK2269557

Summary for 5AE8

Entry DOI	10.2210/pdb5ae8/pdb
Related	5AE9
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 6-(1H-Indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole (3 entities in total)
Functional Keywords	transferase, pi3 kinase delta
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	108264.20
Authors	Down, K.D.,Amour, A.,Baldwin, I.R.,Cooper, A.W.J.,Deakin, A.M.,Felton, L.M.,Guntrip, S.B.,Hardy, C.,Harrison, Z.A.,Jones, K.L.,Jones, P.,Keeling, S.E.,Le, J.,Livia, S.,Lucas, F.,Lunniss, C.J.,Parr, N.J.,Robinson, E.,Rowland, P.,Smith, S.,Thomas, D.A.,Vitulli, G.,Washio, Y.,Hamblin, N. (deposition date: 2015-08-26, release date: 2015-09-16, Last modification date: 2021-09-29)
Primary citation	Down, K.,Amour, A.,Baldwin, I.R.,Cooper, A.W.J.,Deakin, A.M.,Felton, L.M.,Guntrip, S.B.,Hardy, C.,Harrison, Z.A.,Jones, K.L.,Jones, P.,Keeling, S.E.,Le, J.,Livia, S.,Lucas, F.,Lunniss, C.J.,Parr, N.J.,Robinson, E.,Rowland, P.,Smith, S.,Thomas, D.A.,Vitulli, G.,Washio, Y.,Hamblin, J.N. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Gamma for the Treatment of Respiratory Disease. J.Med.Chem., 58:7381-, 2015 Cited by PubMed: 26301626 DOI: 10.1021/ACS.JMEDCHEM.5B00767 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation