5ADJ

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-((3-(2-(Methylamino)ethyl)phenoxy)methyl)quinolin-2- amine

Summary for 5ADJ

• Entry DOI: 10.2210/pdb5adj/pdb
• Related: 5AD4 5AD5 5AD6 5AD7 5AD8 5AD9 5ADA 5ADB 5ADC 5ADD 5ADE 5ADF 5ADG 5ADI 5ADK 5ADL 5ADM 5ADN
• Descriptor: NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
• Functional Keywords: oxidoreductase, nitric oxide synthase, inhibitor complex
• Biological source: BOS TAURUS (BOVINE)
• Cellular location: Cell membrane : P29473
• Total number of polymer chains: 2
• Total formula weight: 102270.05

Authors

Li, H.,Poulos, T.L. (deposition date: 2015-08-20, release date: 2015-10-28, Last modification date: 2015-11-25)

• Primary citation: Cinelli, M.A.,Li, H.,Pensa, A.V.,Kang, S.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.; J.Med.Chem., 58:8694-, 2015; PubMed: 26469213; DOI: 10.1021/ACS.JMEDCHEM.5B01330

Experimental method

X-RAY DIFFRACTION (2.217 Å)