5ADI

Structure of human nNOS R354A G357D mutant heme domain in complex with 7-(((5-((Methylamino)methyl)pyridin-3-yl)oxy)methyl)quinolin-2- amine

Summary for 5ADI

Entry DOI	10.2210/pdb5adi/pdb
Related	5AD4 5AD5 5AD6 5AD7 5AD8 5AD9 5ADA 5ADB 5ADC 5ADD 5ADE 5ADF 5ADG 5ADJ 5ADK 5ADL 5ADM 5ADN
Descriptor	NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywords	oxidoreductase, nitric oxide synthase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein: P29475
Total number of polymer chains	2
Total formula weight	100226.87
Authors	Li, H.,Poulos, T.L. (deposition date: 2015-08-20, release date: 2015-10-28, Last modification date: 2015-11-25)
Primary citation	Cinelli, M.A.,Li, H.,Pensa, A.V.,Kang, S.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58:8694-, 2015 Cited by PubMed: 26469213 DOI: 10.1021/ACS.JMEDCHEM.5B01330 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation