5AD9

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((4-(Dimethylamino)methyl)phenoxy)methyl)quinolin-2- amine

Summary for 5AD9

Related5AD4 5AD5 5AD6 5AD7 5AD8 5ADA 5ADB 5ADC 5ADD 5ADE 5ADF 5ADG 5ADI 5ADJ 5ADK 5ADL 5ADM 5ADN
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsoxidoreductase, nitric oxide synthase, inhibitor complex
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein  P29476
Total number of polymer chains2
Total molecular weight100138.8
Authors
Li, H.,Poulos, T.L. (deposition date: 2015-08-20, release date: 2015-10-28, Last modification date: 2015-11-25)
Primary citation
Cinelli, M.A.,Li, H.,Pensa, A.V.,Kang, S.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
J.Med.Chem., 58:8694-, 2015
PubMed: 26469213 (PDB entries with the same primary citation)
DOI: 10.1021/ACS.JMEDCHEM.5B01330
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25660.4%3.2%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution