5AD2
Bivalent binding to BET bromodomains
Summary for 5AD2
Entry DOI | 10.2210/pdb5ad2/pdb |
Related | 5AD3 |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone (3 entities in total) |
Functional Keywords | transcription |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 2 |
Total formula weight | 30682.75 |
Authors | Waring, M.J.,Chen, H.,Rabow, A.A.,Walker, G.,Bobby, R.,Boiko, S.,Bradbury, R.H.,Callis, R.,Dale, I.,Daniels, D.,Flavell, L.,Holdgate, G.,Jowitt, T.A.,Kikhney, A.,McAlister, M.,Ogg, D.,Patel, J.,Petteruti, P.,Robb, G.R.,Robers, M.,Stratton, N.,Svergun, D.I.,Wang, W.,Whittaker, D. (deposition date: 2015-08-19, release date: 2016-09-28, Last modification date: 2024-01-10) |
Primary citation | Waring, M.J.,Chen, H.,Rabow, A.A.,Walker, G.,Bobby, R.,Boiko, S.,Bradbury, R.H.,Callis, R.,Clark, E.,Dale, I.,Daniels, D.L.,Dulak, A.,Flavell, L.,Holdgate, G.,Jowitt, T.A.,Kikhney, A.,Mcalister, M.,Ogg, D.,Patel, J.,Petteruti, P.,Robb, G.R.,Robers, M.B.,Saif, S.,Stratton, N.,Svergun, D.I.,Wang, W.,Whittaker, D.,Wilson, D.M.,Yao, Y. Potent and Selective Bivalent Inhibitors of Bet Bromodomains Nat.Chem.Biol., 12:1097-, 2016 Cited by PubMed: 27775716DOI: 10.1038/NCHEMBIO.2210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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