5ACB

Crystal Structure of the Human Cdk12-Cyclink Complex

5ACB の概要

• エントリーDOI: 10.2210/pdb5acb/pdb
• 分子名称: CYCLIN-K, CYCLIN-DEPENDENT KINASE 12, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide (3 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Nucleus: Q9NYV4
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 141446.32

構造登録者

Dixon Clarke, S.E.,Elkins, J.M.,Pike, A.C.W.,Mackenzie, A.,Goubin, S.,Strain-Damerell, C.,Mahajan, P.,Tallant, C.,Chalk, R.,Wiggers, H.,Kopec, J.,Fitzpatrick, F.,Burgess-Brown, N.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (登録日: 2015-08-14, 公開日: 2016-06-15, 最終更新日: 2016-10-05)

• 主引用文献: Zhang, T.,Kwiatkowski, N.,Olson, C.M.,Dixon-Clarke, S.E.,Abraham, B.J.,Greifenberg, A.K.,Ficarro, S.B.,Elkins, J.M.,Liang, Y.,Hannett, N.M.,Manz, T.,Hao, M.,Bartkowiak, B.,Greenleaf, A.L.,Marto, J.A.,Geyer, M.,Bullock, A.N.,Young, R.A.,Gray, N.S.; Covalent Targeting of Remote Cysteine Residues to Develop Cdk12 and Cdk13 Inhibitors.; Nat.Chem.Biol., 12:876-, 2016; PubMed: 27571479; DOI: 10.1038/NCHEMBIO.2166

実験手法

X-RAY DIFFRACTION (2.7 Å)