5A97
Hazara virus nucleocapsid protain
Summary for 5A97
| Entry DOI | 10.2210/pdb5a97/pdb |
| Descriptor | NUCLEOCAPSID PROTEIN (2 entities in total) |
| Functional Keywords | viral protein, hazara, nucleocapsid |
| Biological source | HAZARA VIRUS |
| Total number of polymer chains | 4 |
| Total formula weight | 218568.55 |
| Authors | Surtees, R.,Ariza, A.,Hewson, R.,Barr, J.N.,Edwards, T.A. (deposition date: 2015-07-17, release date: 2016-01-13, Last modification date: 2024-01-10) |
| Primary citation | Surtees, R.,Ariza, A.,Punch, E.K.,Trinh, C.H.,Dowall, S.D.,Hewson, R.,Hiscox, J.A.,Barr, J.N.,Edwards, T.A. The Crystal Structure of the Hazara Virus Nucleocapsid Protein. Bmc Struct.Biol., 15:24-, 2015 Cited by PubMed Abstract: Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fatal human disease with a mortality rate approaching 30 %, which has an increased recent incidence within southern Europe. There are no preventative or therapeutic treatments for CCHFV-mediated disease, and thus CCHFV is classified as a hazard group 4 pathogen. In contrast HAZV is not associated with serious human disease, although infection of interferon receptor knockout mice with either CCHFV or HAZV results in similar disease progression. To characterise further similarities between HAZV and CCHFV, and support the use of HAZV as a model for CCHFV infection, we investigated the structure of the HAZV nucleocapsid protein (N) and compared it to CCHFV N. N performs an essential role in the viral life cycle by encapsidating the viral RNA genome, and thus, N represents a potential therapeutic target. PubMed: 26715309DOI: 10.1186/S12900-015-0051-3 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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