5A7R
Human poly(ADP-ribose) glycohydrolase in complex with synthetic dimeric ADP-ribose
Summary for 5A7R
Entry DOI | 10.2210/pdb5a7r/pdb |
Descriptor | POLY(ADP-RIBOSE) GLYCOHYDROLASE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, BETA-MERCAPTOETHANOL, ... (7 entities in total) |
Functional Keywords | hydrolase, parg, adp-ribose |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Nucleus . Isoform 2: Cytoplasm . Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Isoform 5: Mitochondrion matrix: Q86W56 |
Total number of polymer chains | 1 |
Total formula weight | 64255.96 |
Authors | Lambrecht, M.J.,Brichacek, M.,Barkauskaite, E.,Ariza, A.,Ahel, I.,Hergenrother, P.J. (deposition date: 2015-07-09, release date: 2015-07-22, Last modification date: 2024-01-10) |
Primary citation | Lambrecht, M.J.,Brichacek, M.,Barkauskaite, E.,Ariza, A.,Ahel, I.,Hergenrother, P.J. Synthesis of Dimeric Adp-Ribose and its Structure with Human Poly(Adp-Ribose) Glycohydrolase. J.Am.Chem.Soc., 137:3558-, 2015 Cited by PubMed: 25706250DOI: 10.1021/JA512528P PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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