5A3T

Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid).

Summary for 5A3T

Entry DOI	10.2210/pdb5a3t/pdb
Related	5A3N 5A3W
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (8 entities in total)
Functional Keywords	oxidoreductase, lysine-specific demethylase 5b
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q9UGL1
Total number of polymer chains	1
Total formula weight	56615.76
Authors	Srikannathasan, V.,Johansson, C.,Gileadi, C.,Kopec, J.,Strain-Damerell, C.,Kupinska, K.,BurgessBrown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Oppermann, U. (deposition date: 2015-06-02, release date: 2015-06-17, Last modification date: 2016-06-29)
Primary citation	Johansson, C.,Velupillai, S.,Tumber, A.,Szykowska, A.,Hookway, E.S.,Nowak, R.P.,Strain-Damerell, C.,Gileadi, C.,Philpott, M.,Burgess-Brown, N.,Wu, N.,Kopec, J.,Nuzzi, A.,Steuber, H.,Egner, U.,Badock, V.,Munro, S.,Lathangue, N.B.,Westaway, S.,Brown, J.,Athanasou, N.,Prinjha, R.,Brennan, P.E.,Oppermann, U. Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12:539-, 2016 Cited by PubMed: 27214403 DOI: 10.1038/NCHEMBIO.2087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation