5A3T

Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid).

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1754

Chain	Residue
A	CYS692
A	CYS695
A	CYS715
A	HIS718

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE EPE A 1755

Chain	Residue
A	VAL553
A	ARG584
A	TYR586
A	HIS617
A	TYR618
A	LEU621
A	ARG623
A	HOH2117
A	HOH2123
A	HOH2150
A	HOH2241
A	ILE500
A	TRP504
A	LEU541
A	PHE542
A	LEU552

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE MMK A 1756

Chain	Residue
A	ARG98
A	TYR425
A	ASP428
A	TYR488
A	PHE496
A	HIS499
A	GLU501
A	LYS517
A	TRP519
A	HIS587
A	VAL600
A	ASN601
A	MN1765
A	HOH2051
A	HOH2124
A	HOH2129
A	HOH2242

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NI A 1757

Chain	Residue
A	HIS622
A	HIS718

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1758

Chain	Residue
A	ASP630
A	CYS699
A	PHE700
A	MET701
A	SER702
A	HOH2184

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1759

Chain	Residue
A	ARG666
A	THR737
A	HOH2234

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1760

Chain	Residue
A	LEU90
A	ASN91
A	LEU413
A	THR416
A	GLU419
A	ASP420
A	VAL421
A	HOH2087

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1761

Chain	Residue
A	ARG612
A	ASP630
A	MET658
A	GLU662
A	HOH2168

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1762

Chain	Residue
A	PRO465
A	SER470
A	LEU472
A	MET482
A	ASN601
A	PHE602
A	CYS603

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 1763

Chain	Residue
A	GLU468
A	SER470
A	VAL471
A	LEU472
A	ALA473
A	HIS474
A	MET636
A	LEU643
A	VAL647
A	HOH2103

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1764

Chain	Residue
A	ASP688
A	GLU689
A	ARG690
A	GLN691
A	VAL693
A	LEU712
A	LEU713

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1765

Chain	Residue
A	HIS499
A	GLU501
A	HIS587
A	MMK1756
A	HOH2124

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---