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5A3T

Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid).

Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1754
ChainResidue
ACYS692
ACYS695
ACYS715
AHIS718

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE EPE A 1755
ChainResidue
AVAL553
AARG584
ATYR586
AHIS617
ATYR618
ALEU621
AARG623
AHOH2117
AHOH2123
AHOH2150
AHOH2241
AILE500
ATRP504
ALEU541
APHE542
ALEU552

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE MMK A 1756
ChainResidue
AARG98
ATYR425
AASP428
ATYR488
APHE496
AHIS499
AGLU501
ALYS517
ATRP519
AHIS587
AVAL600
AASN601
AMN1765
AHOH2051
AHOH2124
AHOH2129
AHOH2242

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NI A 1757
ChainResidue
AHIS622
AHIS718

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1758
ChainResidue
AASP630
ACYS699
APHE700
AMET701
ASER702
AHOH2184

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 1759
ChainResidue
AARG666
ATHR737
AHOH2234

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 1760
ChainResidue
ALEU90
AASN91
ALEU413
ATHR416
AGLU419
AASP420
AVAL421
AHOH2087

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1761
ChainResidue
AARG612
AASP630
AMET658
AGLU662
AHOH2168

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 1762
ChainResidue
APRO465
ASER470
ALEU472
AMET482
AASN601
APHE602
ACYS603

site_idBC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE EDO A 1763
ChainResidue
AGLU468
ASER470
AVAL471
ALEU472
AALA473
AHIS474
AMET636
ALEU643
AVAL647
AHOH2103

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 1764
ChainResidue
AASP688
AGLU689
AARG690
AGLN691
AVAL693
ALEU712
ALEU713

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 1765
ChainResidue
AHIS499
AGLU501
AHIS587
AMMK1756
AHOH2124

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues52
DetailsZN_FING: C5HC2 => ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558
ChainResidueDetails
ACYS692-MET744

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P29375
ChainResidueDetails
ATYR425
ASER507
AASN509
ALYS517

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000305|PubMed:26741168, ECO:0000305|PubMed:27214403, ECO:0000305|PubMed:28262558
ChainResidueDetails
AHIS499
AGLU501
AHIS587

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS769

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PDB entries from 2024-11-06

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