5ZC6

Solution structure of H-RasT35S mutant protein in complex with KBFM123

Summary for 5ZC6

• Entry DOI: 10.2210/pdb5zc6/pdb
• Related: 2LCF 2LWI
• NMR Information: BMRB: 36166
• Descriptor: GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, 3-oxidanyl-~{N}-[[(2~{R})-oxolan-2-yl]methyl]naphthalene-2-carboxamide, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, cancer, small gtpases, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 19678.98

Authors

Matsumoto, S.,Hayashi, Y.,Hiraga, T.,Matsuo, K.,Kataoka, T. (deposition date: 2018-02-15, release date: 2018-09-12, Last modification date: 2024-05-01)

• Primary citation: Matsumoto, S.,Hiraga, T.,Hayashi, Y.,Yoshikawa, Y.,Tsuda, C.,Araki, M.,Neya, M.,Shima, F.,Kataoka, T.; Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring; Biochemistry, 57:5350-5358, 2018; PubMed: 30141910; DOI: 10.1021/acs.biochem.8b00680

Experimental method

SOLUTION NMR