5YJF
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with small molecule analog of Nicotinamide
Summary for 5YJF
Entry DOI | 10.2210/pdb5yjf/pdb |
Descriptor | Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 6-methoxy-1-methyl-2H-pyridine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | nnmt, na, mna, t2d, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P40261 |
Total number of polymer chains | 4 |
Total formula weight | 128627.15 |
Authors | Swaminathan, S.,Birudukota, S.,Thakur, M.K.,Parveen, R.,Kandan, S.,Hallur, M.S.,Rajagopal, S.,Ruf, S.,Dhakshinamoorthy, S.,Kannt, A.,Gosu, R. (deposition date: 2017-10-10, release date: 2018-03-21, Last modification date: 2023-11-22) |
Primary citation | Kannt, A.,Rajagopal, S.,Kadnur, S.V.,Suresh, J.,Bhamidipati, R.K.,Swaminathan, S.,Hallur, M.S.,Kristam, R.,Elvert, R.,Czech, J.,Pfenninger, A.,Rudolph, C.,Schreuder, H.,Chandrasekar, D.V.,Mane, V.S.,Birudukota, S.,Shaik, S.,Zope, B.R.,Burri, R.R.,Anand, N.N.,Thakur, M.K.,Singh, M.,Parveen, R.,Kandan, S.,Mullangi, R.,Yura, T.,Gosu, R.,Ruf, S.,Dhakshinamoorthy, S. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep, 8:3660-3660, 2018 Cited by PubMed: 29483571DOI: 10.1038/s41598-018-22081-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.49 Å) |
Structure validation
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