5XE1
Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with INCB14943
Summary for 5XE1
Entry DOI | 10.2210/pdb5xe1/pdb |
Descriptor | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboxamidine (3 entities in total) |
Functional Keywords | ido1, incb14943, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : P14902 |
Total number of polymer chains | 2 |
Total formula weight | 92544.67 |
Authors | |
Primary citation | Wu, Y.,Xu, T.,Liu, J.,Ding, K.,Xu, J. Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943 Biochem. Biophys. Res. Commun., 487:339-343, 2017 Cited by PubMed: 28412361DOI: 10.1016/j.bbrc.2017.04.061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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