5WB8
Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Summary for 5WB8
Entry DOI | 10.2210/pdb5wb8/pdb |
Descriptor | Epidermal growth factor receptor, Epigen, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | receptor tyrosine kinase, growth factor, signaling, membrane protein, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 129970.76 |
Authors | Bessman, N.J.,Freed, D.M.,Moore, J.O.,Ferguson, K.M.,Lemmon, M.A. (deposition date: 2017-06-28, release date: 2017-10-18, Last modification date: 2023-10-04) |
Primary citation | Freed, D.M.,Bessman, N.J.,Kiyatkin, A.,Salazar-Cavazos, E.,Byrne, P.O.,Moore, J.O.,Valley, C.C.,Ferguson, K.M.,Leahy, D.J.,Lidke, D.S.,Lemmon, M.A. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell, 171:683-695.e18, 2017 Cited by PubMed: 28988771DOI: 10.1016/j.cell.2017.09.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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