5W2H
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with Ins(1,4,5)P3 and ADP
Summary for 5W2H
Entry DOI | 10.2210/pdb5w2h/pdb |
Related | 5W2G 5W2I |
Descriptor | Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | kinase, inositol, inositol polyphosphate, phosphatidylinositol, specificity, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q8NFU5 |
Total number of polymer chains | 1 |
Total formula weight | 30418.34 |
Authors | Wang, H.,Shears, S.B. (deposition date: 2017-06-06, release date: 2017-09-13, Last modification date: 2023-10-04) |
Primary citation | Wang, H.,Shears, S.B. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J. Biol. Chem., 292:18192-18202, 2017 Cited by PubMed: 28882892DOI: 10.1074/jbc.M117.801845 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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