5W2H
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with Ins(1,4,5)P3 and ADP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 701 |
| Chain | Residue |
| A | ASP385 |
| A | ADP703 |
| A | HOH854 |
| A | HOH903 |
| A | HOH925 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | HOH859 |
| A | HOH919 |
| A | ASP385 |
| A | ADP703 |
| A | HOH803 |
| A | HOH849 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue ADP A 703 |
| Chain | Residue |
| A | ILE65 |
| A | VAL73 |
| A | LYS75 |
| A | PRO111 |
| A | GLU131 |
| A | ASP132 |
| A | VAL133 |
| A | ASP144 |
| A | LEU254 |
| A | ASP385 |
| A | MG701 |
| A | MG702 |
| A | HOH803 |
| A | HOH854 |
| A | HOH884 |
| A | HOH895 |
| A | HOH903 |
| A | HOH908 |
| A | HOH919 |
| A | HOH925 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue I3P A 704 |
| Chain | Residue |
| A | ARG82 |
| A | LYS146 |
| A | LYS160 |
| A | GLN163 |
| A | GLN164 |
| A | LYS167 |
| A | GLN196 |
| A | ALA250 |
| A | HIS388 |
| A | PO4705 |
| A | HOH812 |
| A | HOH819 |
| A | HOH846 |
| A | HOH849 |
| A | HOH871 |
| A | HOH877 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 705 |
| Chain | Residue |
| A | LYS167 |
| A | ARG200 |
| A | ARG200 |
| A | I3P704 |
| A | HOH900 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28882892","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5W2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W2I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28882892","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5W2H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
