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5W2H

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with Ins(1,4,5)P3 and ADP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AInositol polyphosphate multikinase,Inositol polyphosphate multikinasepolymer25729427.51UniProt (Q8NFU5)
Pfam (PF03770)
In PDB
Homo sapiens (Human)Inositol 1,3,4,6-tetrakisphosphate 5-kinase,Inositol 1,3,4,6-tetrakisphosphate 5-kinase
2AMAGNESIUM IONnon-polymer24.32Chemie (MG)
3AADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
4AD-MYO-INOSITOL-1,4,5-TRIPHOSPHATEnon-polymer420.11Chemie (I3P)
5APHOSPHATE IONnon-polymer95.01Chemie (PO4)
6waterwater18.0172Chemie (HOH)
Sequence modifications
A: 54 - 372 (UniProt: Q8NFU5)
PDBExternal DatabaseDetails
Gly 50-expression tag
Ser 51-expression tag
Phe 52-expression tag
Thr 53-expression tag
-Asp 61deletion
-Lys 62deletion
-Val 63deletion
-Gly 64deletion
A: 378 - 416 (UniProt: Q8NFU5)
PDBExternal DatabaseDetails
Gly 373-linker
Gly 374-linker
Ser 375-linker
Gly 376-linker
Gly 377-linker
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight29427.5
Non-Polymers*Number of molecules5
Total formula weight990.9
All*Total formula weight30418.3
*Water molecules are not included.

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PDB entries from 2024-09-04

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