5W2H
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with Ins(1,4,5)P3 and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inositol polyphosphate multikinase,Inositol polyphosphate multikinase | polymer | 257 | 29427.5 | 1 | UniProt (Q8NFU5) Pfam (PF03770) | Homo sapiens (Human) | Inositol 1,3,4,6-tetrakisphosphate 5-kinase,Inositol 1,3,4,6-tetrakisphosphate 5-kinase |
| 2 | B, C (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | E (A) | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE | non-polymer | 420.1 | 1 | Chemie (I3P) | |||
| 5 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | G (A) | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A: 54 - 372 (UniProt: Q8NFU5)
A: 378 - 416 (UniProt: Q8NFU5)
| PDB | External Database | Details |
|---|---|---|
| Gly 50 | - | expression tag |
| Ser 51 | - | expression tag |
| Phe 52 | - | expression tag |
| Thr 53 | - | expression tag |
| - | Asp 61 | deletion |
| - | Lys 62 | deletion |
| - | Val 63 | deletion |
| - | Gly 64 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Gly 373 | - | linker |
| Gly 374 | - | linker |
| Ser 375 | - | linker |
| Gly 376 | - | linker |
| Gly 377 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29427.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 990.9 | |
| All* | Total formula weight | 30418.3 |
