5VU0
Crystal structure of the complex between afucosylated/galactosylated human IgG1 Fc and Fc gamma receptor IIIa (CD16A) with Man5 N-glycans
Summary for 5VU0
Entry DOI | 10.2210/pdb5vu0/pdb |
Descriptor | Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | complex, glycosylated, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 73095.36 |
Authors | Subedi, G.S.,Marcella, A.M.,Barb, A.W. (deposition date: 2017-05-18, release date: 2018-05-23, Last modification date: 2023-10-04) |
Primary citation | Falconer, D.J.,Subedi, G.P.,Marcella, A.M.,Barb, A.W. Antibody Fucosylation Lowers the Fc gamma RIIIa/CD16a Affinity by Limiting the Conformations Sampled by the N162-Glycan. ACS Chem. Biol., 13:2179-2189, 2018 Cited by PubMed: 30016589DOI: 10.1021/acschembio.8b00342 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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