5VSK
Structure of DUB complex
Summary for 5VSK
Entry DOI | 10.2210/pdb5vsk/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, ZINC ION, ... (4 entities in total) |
Functional Keywords | deubiquitinase, inhibitor, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q93009 |
Total number of polymer chains | 2 |
Total formula weight | 83150.19 |
Authors | Seo, H.-Y.,Dhe-Paganon, S. (deposition date: 2017-05-11, release date: 2017-12-20, Last modification date: 2018-01-03) |
Primary citation | Lamberto, I.,Liu, X.,Seo, H.S.,Schauer, N.J.,Iacob, R.E.,Hu, W.,Das, D.,Mikhailova, T.,Weisberg, E.L.,Engen, J.R.,Anderson, K.C.,Chauhan, D.,Dhe-Paganon, S.,Buhrlage, S.J. Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chem Biol, 24:1490-1500.e11, 2017 Cited by PubMed: 29056421DOI: 10.1016/j.chembiol.2017.09.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.33 Å) |
Structure validation
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