5V49
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1917)
Summary for 5V49
Entry DOI | 10.2210/pdb5v49/pdb |
Descriptor | Methionyl-tRNA synthetase, putative, METHIONINE, N~1~-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N~2~-[(4R)-6,8-dichloro-1,2,3,4-tetrahydroquinolin-4-yl]-N~1~-methylethane-1,2-diamine, ... (5 entities in total) |
Functional Keywords | synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 2 |
Total formula weight | 123328.48 |
Authors | Barros-Alvarez, X.,Hol, W.G.J. (deposition date: 2017-03-08, release date: 2017-07-26, Last modification date: 2024-03-06) |
Primary citation | Huang, W.,Zhang, Z.,Ranade, R.M.,Gillespie, J.R.,Barros-Alvarez, X.,Creason, S.A.,Shibata, S.,Verlinde, C.L.M.J.,Hol, W.G.J.,Buckner, F.S.,Fan, E. Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Bioorg. Med. Chem. Lett., 27:2702-2707, 2017 Cited by PubMed: 28465105DOI: 10.1016/j.bmcl.2017.04.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report