5UTZ
Human IL-2/Fab complex
Summary for 5UTZ
Entry DOI | 10.2210/pdb5utz/pdb |
Descriptor | Fab 5111 heavy chain, Fab 5111 light chain, Interleukin-2, ... (5 entities in total) |
Functional Keywords | cytokine, fab, complex, cytokine-immune system complex, cytokine/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 249703.99 |
Authors | Jude, K.M.,Garcia, K.C. (deposition date: 2017-02-15, release date: 2018-07-11, Last modification date: 2023-10-04) |
Primary citation | Trotta, E.,Bessette, P.H.,Silveria, S.L.,Ely, L.K.,Jude, K.M.,Le, D.T.,Holst, C.R.,Coyle, A.,Potempa, M.,Lanier, L.L.,Garcia, K.C.,Crellin, N.K.,Rondon, I.J.,Bluestone, J.A. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med., 24:1005-1014, 2018 Cited by PubMed: 29942088DOI: 10.1038/s41591-018-0070-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.747 Å) |
Structure validation
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