5UQY

Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78

Replaces:  3X2D

Summary for 5UQY

• Entry DOI: 10.2210/pdb5uqy/pdb
• Descriptor: ENVELOPE GLYCOPROTEIN GP1, alpha-D-mannopyranose, ENVELOPE GLYCOPROTEIN GP2, ... (10 entities in total)
• Functional Keywords: glycoprotein, viral protein, antibody, fab, viral protein-immune system complex, viral protein/immune system
• Biological source: Lake Victoria marburgvirus (strain Ravn-87) (MARV); More
• Total number of polymer chains: 16
• Total formula weight: 412484.12

Authors

Hashiguchi, T.,Fusco, M.L.,Hastie, K.M.,Bomholdt, Z.A.,Lee, J.E.,Flyak, A.I.,Matsuoka, R.,Kohda, D.,Yanagi, Y.,Hammel, M.,Crowe, J.E.,Saphire, E.O. (deposition date: 2017-02-08, release date: 2017-03-01, Last modification date: 2023-10-04)

• Primary citation: Hashiguchi, T.,Fusco, M.L.,Bornholdt, Z.A.,Lee, J.E.,Flyak, A.I.,Matsuoka, R.,Kohda, D.,Yanagi, Y.,Hammel, M.,Crowe, J.E.,Saphire, E.O.; Structural basis for Marburg virus neutralization by a cross-reactive human antibody.; Cell, 160:904-912, 2015; PubMed: 25723165; DOI: 10.1016/j.cell.2015.01.041

Experimental method

X-RAY DIFFRACTION (3.6 Å)