5UQY
Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78
Replaces: 3X2DEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I, M (A, E, I, M) | ENVELOPE GLYCOPROTEIN GP1 | polymer | 250 | 27885.4 | 4 | UniProt (Q1PDC7) Pfam (PF01611) | Lake Victoria marburgvirus (strain Ravn-87) (MARV) | GP1,2,GP,Virion spike glycoprotein,GP1,2,GP,Virion spike glycoprotein |
| 2 | B, F, J, N (B, F, J, N) | ENVELOPE GLYCOPROTEIN GP2 | polymer | 237 | 26137.6 | 4 | UniProt (Q1PDC7) Pfam (PF22307) | Lake Victoria marburgvirus (strain Ravn-87) (MARV) | GP1,2,GP,Virion spike glycoprotein |
| 3 | C, G, K, O (C, G, K, O) | MR78 Fab light chain | polymer | 211 | 23307.9 | 4 | Homo sapiens (Human) | ||
| 4 | D, H, L, P (D, H, L, P) | MR78 Fab heavy chain | polymer | 226 | 23869.6 | 4 | Homo sapiens (Human) | ||
| 5 | Q, R, T, W, Y... (Q, R, T, W, Y...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 6 | S, U (S, U) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G56014GC) | |||
| 7 | V, X (V, X) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 8 | AA (a) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
| 9 | BA (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 10 | CA, DA (I, M) | alpha-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (MAN) |
Sequence modifications
A, E, I, M: 17 - 256 (UniProt: Q1PDC7)
A, E, I, M: 257 - 266 (UniProt: Q1PDC7)
B, F, J, N: 436 - 637 (UniProt: Q1PDC7)
A, E, I, M: 257 - 266 (UniProt: Q1PDC7)
B, F, J, N: 436 - 637 (UniProt: Q1PDC7)
| PDB | External Database | Details |
|---|---|---|
| Leu 438 | Phe 438 | engineered mutation |
| Ala 439 | Trp 439 | engineered mutation |
| Gly 445 | Phe 445 | engineered mutation |
| Asn 447 | Phe 447 | engineered mutation |
| Asp 638 | - | expression tag |
| Asp 639 | - | expression tag |
| Asp 640 | - | expression tag |
| Asp 641 | - | expression tag |
| Lys 642 | - | expression tag |
| Ala 643 | - | expression tag |
| Gly 644 | - | expression tag |
| Trp 645 | - | expression tag |
| Ser 646 | - | expression tag |
| His 647 | - | expression tag |
| Pro 648 | - | expression tag |
| Gln 649 | - | expression tag |
| Phe 650 | - | expression tag |
| Glu 651 | - | expression tag |
| Lys 652 | - | expression tag |
| Gly 653 | - | expression tag |
| Gly 654 | - | expression tag |
| Gly 655 | - | expression tag |
| Ser 656 | - | expression tag |
| Gly 657 | - | expression tag |
| Gly 658 | - | expression tag |
| Gly 659 | - | expression tag |
| Ser 660 | - | expression tag |
| Gly 661 | - | expression tag |
| Gly 662 | - | expression tag |
| Gly 663 | - | expression tag |
| Ser 664 | - | expression tag |
| Trp 665 | - | expression tag |
| Ser 666 | - | expression tag |
| His 667 | - | expression tag |
| Pro 668 | - | expression tag |
| Gln 669 | - | expression tag |
| Phe 670 | - | expression tag |
| Glu 671 | - | expression tag |
| Lys 672 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 404802.1 | |
| Branched | Number of molecules | 11 |
| Total formula weight | 7100.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 581.5 | |
| All* | Total formula weight | 412484.1 |
