5UGH
Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366
Summary for 5UGH
| Entry DOI | 10.2210/pdb5ugh/pdb |
| Descriptor | S-adenosylmethionine synthase isoform type-2, 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine (3 entities in total) |
| Functional Keywords | mat2a, sam, methionine adenosyltransferase, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 176862.40 |
| Authors | Kaiser, S.E.,Feng, J.,Stewart, A.E. (deposition date: 2017-01-08, release date: 2017-05-17, Last modification date: 2023-10-04) |
| Primary citation | Quinlan, C.L.,Kaiser, S.E.,Bolanos, B.,Nowlin, D.,Grantner, R.,Karlicek-Bryant, S.,Feng, J.L.,Jenkinson, S.,Freeman-Cook, K.,Dann, S.G.,Wang, X.,Wells, P.A.,Fantin, V.R.,Stewart, A.E.,Grant, S.K. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat. Chem. Biol., 13:785-792, 2017 Cited by PubMed: 28553945DOI: 10.1038/nchembio.2384 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.062 Å) |
Structure validation
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