5UGH
Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004478 | molecular_function | methionine adenosyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005829 | cellular_component | cytosol |
A | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016740 | molecular_function | transferase activity |
A | 0034214 | biological_process | protein hexamerization |
A | 0036094 | molecular_function | small molecule binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0048269 | cellular_component | methionine adenosyltransferase complex |
A | 0051291 | biological_process | protein heterooligomerization |
A | 0061431 | biological_process | cellular response to methionine |
A | 1904263 | biological_process | positive regulation of TORC1 signaling |
A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
B | 0004478 | molecular_function | methionine adenosyltransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005829 | cellular_component | cytosol |
B | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016740 | molecular_function | transferase activity |
B | 0034214 | biological_process | protein hexamerization |
B | 0036094 | molecular_function | small molecule binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0048269 | cellular_component | methionine adenosyltransferase complex |
B | 0051291 | biological_process | protein heterooligomerization |
B | 0061431 | biological_process | cellular response to methionine |
B | 1904263 | biological_process | positive regulation of TORC1 signaling |
B | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
C | 0004478 | molecular_function | methionine adenosyltransferase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005829 | cellular_component | cytosol |
C | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0016740 | molecular_function | transferase activity |
C | 0034214 | biological_process | protein hexamerization |
C | 0036094 | molecular_function | small molecule binding |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0048269 | cellular_component | methionine adenosyltransferase complex |
C | 0051291 | biological_process | protein heterooligomerization |
C | 0061431 | biological_process | cellular response to methionine |
C | 1904263 | biological_process | positive regulation of TORC1 signaling |
C | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
D | 0004478 | molecular_function | methionine adenosyltransferase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005829 | cellular_component | cytosol |
D | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0016740 | molecular_function | transferase activity |
D | 0034214 | biological_process | protein hexamerization |
D | 0036094 | molecular_function | small molecule binding |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0048269 | cellular_component | methionine adenosyltransferase complex |
D | 0051291 | biological_process | protein heterooligomerization |
D | 0061431 | biological_process | cellular response to methionine |
D | 1904263 | biological_process | positive regulation of TORC1 signaling |
D | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue 8AJ A 401 |
Chain | Residue |
A | LEU315 |
C | PHE18 |
C | PHE20 |
C | GLN190 |
C | GLY273 |
C | TRP274 |
A | GLN317 |
A | SER331 |
A | ILE332 |
A | PHE333 |
A | GLU342 |
C | GLU15 |
C | GLY16 |
C | THR17 |
site_id | AC2 |
Number of Residues | 14 |
Details | binding site for residue 8AJ B 401 |
Chain | Residue |
B | GLN317 |
B | SER331 |
B | ILE332 |
B | PHE333 |
B | GLU342 |
B | HOH547 |
D | GLU15 |
D | GLY16 |
D | THR17 |
D | PHE18 |
D | PHE20 |
D | GLN190 |
D | GLY273 |
D | TRP274 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue 8AJ B 402 |
Chain | Residue |
B | PHE18 |
B | PHE20 |
B | GLN190 |
B | GLY273 |
B | TRP274 |
B | HOH535 |
D | LEU315 |
D | SER331 |
D | ILE332 |
D | PHE333 |
D | GLU342 |
site_id | AC4 |
Number of Residues | 13 |
Details | binding site for residue 8AJ C 401 |
Chain | Residue |
A | GLU15 |
A | PHE18 |
A | PHE20 |
A | GLN190 |
A | GLY273 |
A | TRP274 |
C | LEU315 |
C | GLN317 |
C | SER331 |
C | ILE332 |
C | PHE333 |
C | GLU342 |
C | HOH534 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: in other chain => ECO:0000305|PubMed:25075345, ECO:0000305|PubMed:26858410, ECO:0007744|PDB:4NDN, ECO:0007744|PDB:5A19 |
Chain | Residue | Details |
A | HIS29 | |
A | ARG264 | |
B | HIS29 | |
B | ARG264 | |
C | HIS29 | |
C | ARG264 | |
D | HIS29 | |
D | ARG264 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25075345, ECO:0000305|PubMed:26858410, ECO:0007744|PDB:4KTT, ECO:0007744|PDB:4NDN, ECO:0007744|PDB:5A19, ECO:0007744|PDB:5A1G, ECO:0007744|PDB:5A1I |
Chain | Residue | Details |
A | ASP31 | |
B | ASP31 | |
C | ASP31 | |
D | ASP31 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A817 |
Chain | Residue | Details |
A | GLU57 | |
B | GLU57 | |
C | GLU57 | |
D | GLU57 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000305|PubMed:25075345, ECO:0007744|PDB:4NDN |
Chain | Residue | Details |
A | GLU70 | |
B | GLU70 | |
C | GLU70 | |
D | GLU70 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000305|PubMed:25075345 |
Chain | Residue | Details |
A | GLN113 | |
B | GLN113 | |
C | GLN113 | |
D | GLN113 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000305|PubMed:25075345, ECO:0000305|PubMed:26858410, ECO:0007744|PDB:4KTT, ECO:0007744|PDB:4NDN, ECO:0007744|PDB:5A19, ECO:0007744|PDB:5A1G, ECO:0007744|PDB:5A1I |
Chain | Residue | Details |
A | ASP179 | |
B | ASP179 | |
C | ASP179 | |
D | ASP179 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000305|PubMed:25075345, ECO:0000305|PubMed:26858410, ECO:0007744|PDB:4KTT, ECO:0007744|PDB:4NDN, ECO:0007744|PDB:5A1G, ECO:0007744|PDB:5A1I |
Chain | Residue | Details |
A | SER247 | |
B | SER247 | |
C | SER247 | |
D | SER247 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25075345, ECO:0000305|PubMed:26858410, ECO:0007744|PDB:4NDN, ECO:0007744|PDB:5A1I |
Chain | Residue | Details |
A | ASP258 | |
B | ASP258 | |
C | ASP258 | |
D | ASP258 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25075345, ECO:0007744|PDB:4NDN |
Chain | Residue | Details |
A | ALA281 | |
B | ALA281 | |
C | ALA281 | |
D | ALA281 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25075345, ECO:0000305|PubMed:26858410, ECO:0007744|PDB:4NDN |
Chain | Residue | Details |
A | LYS285 | |
A | ASP291 | |
B | LYS285 | |
B | ASP291 | |
C | LYS285 | |
C | ASP291 | |
D | LYS285 | |
D | ASP291 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000250|UniProtKB:P0A817 |
Chain | Residue | Details |
A | LYS289 | |
B | LYS289 | |
C | LYS289 | |
D | LYS289 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS81 | |
B | LYS81 | |
C | LYS81 | |
D | LYS81 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | SER114 | |
B | SER114 | |
C | SER114 | |
D | SER114 |
site_id | SWS_FT_FI14 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER384 | |
B | SER384 | |
C | SER384 | |
D | SER384 |
site_id | SWS_FT_FI15 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS228 | |
D | LYS228 | |
D | LYS234 | |
A | LYS234 | |
B | LYS228 | |
B | LYS234 | |
C | LYS228 | |
C | LYS234 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 14 |
Details | M-CSA 9 |
Chain | Residue | Details |
A | HIS29 | proton acceptor, proton donor |
A | ARG264 | electrostatic stabiliser |
A | LYS265 | electrostatic stabiliser |
A | LYS285 | electrostatic stabiliser |
A | LYS289 | electrostatic stabiliser |
A | ASP291 | electrostatic stabiliser |
A | ASP31 | electrostatic stabiliser, metal ligand |
A | LYS32 | electrostatic stabiliser |
A | GLU57 | metal ligand |
A | GLU70 | electrostatic stabiliser, steric role |
A | LYS181 | electrostatic stabiliser |
A | PHE250 | steric role |
A | ASP258 | electrostatic stabiliser, metal ligand, steric role |
A | ALA259 | metal ligand |
site_id | MCSA2 |
Number of Residues | 14 |
Details | M-CSA 9 |
Chain | Residue | Details |
B | HIS29 | proton acceptor, proton donor |
B | ARG264 | electrostatic stabiliser |
B | LYS265 | electrostatic stabiliser |
B | LYS285 | electrostatic stabiliser |
B | LYS289 | electrostatic stabiliser |
B | ASP291 | electrostatic stabiliser |
B | ASP31 | electrostatic stabiliser, metal ligand |
B | LYS32 | electrostatic stabiliser |
B | GLU57 | metal ligand |
B | GLU70 | electrostatic stabiliser, steric role |
B | LYS181 | electrostatic stabiliser |
B | PHE250 | steric role |
B | ASP258 | electrostatic stabiliser, metal ligand, steric role |
B | ALA259 | metal ligand |
site_id | MCSA3 |
Number of Residues | 14 |
Details | M-CSA 9 |
Chain | Residue | Details |
C | HIS29 | proton acceptor, proton donor |
C | ARG264 | electrostatic stabiliser |
C | LYS265 | electrostatic stabiliser |
C | LYS285 | electrostatic stabiliser |
C | LYS289 | electrostatic stabiliser |
C | ASP291 | electrostatic stabiliser |
C | ASP31 | electrostatic stabiliser, metal ligand |
C | LYS32 | electrostatic stabiliser |
C | GLU57 | metal ligand |
C | GLU70 | electrostatic stabiliser, steric role |
C | LYS181 | electrostatic stabiliser |
C | PHE250 | steric role |
C | ASP258 | electrostatic stabiliser, metal ligand, steric role |
C | ALA259 | metal ligand |
site_id | MCSA4 |
Number of Residues | 14 |
Details | M-CSA 9 |
Chain | Residue | Details |
D | HIS29 | proton acceptor, proton donor |
D | ARG264 | electrostatic stabiliser |
D | LYS265 | electrostatic stabiliser |
D | LYS285 | electrostatic stabiliser |
D | LYS289 | electrostatic stabiliser |
D | ASP291 | electrostatic stabiliser |
D | ASP31 | electrostatic stabiliser, metal ligand |
D | LYS32 | electrostatic stabiliser |
D | GLU57 | metal ligand |
D | GLU70 | electrostatic stabiliser, steric role |
D | LYS181 | electrostatic stabiliser |
D | PHE250 | steric role |
D | ASP258 | electrostatic stabiliser, metal ligand, steric role |
D | ALA259 | metal ligand |