5UEH
Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate
Summary for 5UEH
Entry DOI | 10.2210/pdb5ueh/pdb |
Descriptor | Glutathione S-transferase omega-1, 2-(4-chlorophenyl)-6-[(fluorosulfonyl)oxy]quinoline-4-carboxylic acid, SULFATE ION, ... (5 entities in total) |
Functional Keywords | arylfluorosulfate, gst, covalent inhibitor, transferase-oxidoreductase complex, transferase/oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : P78417 |
Total number of polymer chains | 1 |
Total formula weight | 28641.10 |
Authors | Mortenson, D.E.,Wilson, I.A.,Kelly, J.W. (deposition date: 2017-01-02, release date: 2018-01-17, Last modification date: 2023-10-04) |
Primary citation | Mortenson, D.E.,Brighty, G.J.,Plate, L.,Bare, G.,Chen, W.,Li, S.,Wang, H.,Cravatt, B.F.,Forli, S.,Powers, E.T.,Sharpless, K.B.,Wilson, I.A.,Kelly, J.W. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. J. Am. Chem. Soc., 140:200-210, 2018 Cited by PubMed: 29265822DOI: 10.1021/jacs.7b08366 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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