5TXY
Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase
Summary for 5TXY
Entry DOI | 10.2210/pdb5txy/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, FORMIC ACID, ... (5 entities in total) |
Functional Keywords | human carbonic anhydrase, zinc binding chemotype, crystal, crystallization, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29577.65 |
Authors | Ren, B.,Peat, T.S.,Poulsen, S.-A. (deposition date: 2016-11-17, release date: 2017-08-30, Last modification date: 2024-03-06) |
Primary citation | Chrysanthopoulos, P.K.,Mujumdar, P.,Woods, L.A.,Dolezal, O.,Ren, B.,Peat, T.S.,Poulsen, S.A. Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60:7333-7349, 2017 Cited by PubMed: 28817930DOI: 10.1021/acs.jmedchem.7b00606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.206 Å) |
Structure validation
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