5TTZ
Crystal structure of Grp94 bound to isoform-selective inhibitor methyl 2-(2-(1-(4-bromobenzyl)-1H-imidazol-2-yl)ethyl)-3-chloro-4,6-dihydroxybenzoate
Summary for 5TTZ
Entry DOI | 10.2210/pdb5ttz/pdb |
Descriptor | Endoplasmin, methyl 2-(2-{1-[(4-bromophenyl)methyl]-1H-imidazol-2-yl}ethyl)-3-chloro-4,6-dihydroxybenzoate, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
Functional Keywords | bnim scaffold, atp binding site, chaperone - inhibitor complex, chaperone / inhibitor |
Biological source | Canis lupus familiaris (Dog) |
Total number of polymer chains | 2 |
Total formula weight | 54111.64 |
Authors | Lieberman, R.L.,Huard, D.J.E. (deposition date: 2016-11-04, release date: 2018-01-10, Last modification date: 2023-10-04) |
Primary citation | Stothert, A.R.,Suntharalingam, A.,Tang, X.,Crowley, V.M.,Mishra, S.J.,Webster, J.M.,Nordhues, B.A.,Huard, D.J.E.,Passaglia, C.L.,Lieberman, R.L.,Blagg, B.S.J.,Blair, L.J.,Koren, J.,Dickey, C.A. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Sci Rep, 7:17951-17951, 2017 Cited by PubMed: 29263415DOI: 10.1038/s41598-017-18344-4 PDB entries with the same primary citation |
Experimental method |
Structure validation
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