5TKD
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE
Summary for 5TKD
Entry DOI | 10.2210/pdb5tkd/pdb |
Descriptor | Non-receptor tyrosine-protein kinase TYK2, 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, tyk2, pseudokinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 67538.56 |
Authors | Muckelbauer, J.K. (deposition date: 2016-10-06, release date: 2016-12-28, Last modification date: 2023-10-04) |
Primary citation | Moslin, R.,Gardner, D.,Santella, J.,Zhang, Y.,Duncia, J.V.,Liu, C.,Lin, J.,Tokarski, J.S.,Strnad, J.,Pedicord, D.,Chen, J.,Blat, Y.,Zupa-Fernandez, A.,Cheng, L.,Sun, H.,Chaudhry, C.,Huang, C.,D'Arienzo, C.,Sack, J.S.,Muckelbauer, J.K.,Chang, C.,Tredup, J.,Xie, D.,Aranibar, N.,Burke, J.R.,Carter, P.H.,Weinstein, D.S. Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm, 8:700-712, 2017 Cited by PubMed: 30108788DOI: 10.1039/c6md00560h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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