5TBI
Crystal structure of mouse CARM1 in complex with inhibitor LH1427
Summary for 5TBI
Entry DOI | 10.2210/pdb5tbi/pdb |
Descriptor | Histone-arginine methyltransferase CARM1, 1,2-ETHANEDIOL, 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine, ... (6 entities in total) |
Functional Keywords | protein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 4 |
Total formula weight | 166493.15 |
Authors | Cura, V.,Marechal, N.,Troffer-Charlier, N.,Halby, L.,Arimondo, P.,Bonnefond, L.,Cavarelli, J. (deposition date: 2016-09-12, release date: 2017-09-20, Last modification date: 2024-01-17) |
Primary citation | Halby, L.,Marechal, N.,Pechalrieu, D.,Cura, V.,Franchini, D.M.,Faux, C.,Alby, F.,Troffer-Charlier, N.,Kudithipudi, S.,Jeltsch, A.,Aouadi, W.,Decroly, E.,Guillemot, J.C.,Page, P.,Ferroud, C.,Bonnefond, L.,Guianvarc'h, D.,Cavarelli, J.,Arimondo, P.B. Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos.Trans.R.Soc.Lond.B Biol.Sci., 373:-, 2018 Cited by PubMed: 29685976DOI: 10.1098/rstb.2017.0072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.294 Å) |
Structure validation
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